Barbiturates can induce hepatic microsomal enzymes causing elevated metabolism and lessened anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people stabilized on anticoagulant therapy may call for dosage changes if barbiturates are extra to or withdrawn from their dosage routine
pentobarbital will increase the level or effect of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the extent or impact of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Induction of microsomal enzymes by this drug, may possibly shorten the 50 percent-life of doxycycline for as long as 2 weeks following barbiturate therapy discontinued; check medical response to doxycycline carefully if both equally medications administered concurrently
pentobarbital will lessen the level or effect of voriconazole by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Not known.
pentobarbital will lower the extent or influence of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will decrease the extent or result of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
Purchasing drug levels from the blood or urine, proper laboratory checks, and imaging inside the emergency Division.
pentobarbital will reduce the extent or influence of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
pentobarbital decreases levels of amphotericin B deoxycholate by click here inhibition of GI absorption. Applies only to oral form of both equally agents. Insignificant/Significance Mysterious.
pentobarbital will reduce the level or result of bazedoxifene/conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may possibly raise the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will minimize the level or effect of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Robust CYP3A4 inducers could minimize midostaurin concentrations leading to reduced efficacy.
pentobarbital will minimize the level or impact of finasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.